|Name||Function||Tissue specific expression||Citation|
|piwi-1||Protein that promotes stem cell maintenance and differentiation.||stem cells (neoblasts)||Reddien et al., 2005|
|pc2||Enzyme whose activity is the proteolytic processing of prohormones to mature neuropeptides.||nervous system||Collins et al., 2010|
|opsin-like||Light-sensitive proteins with the ability to convert photons (light) into electrochemical signal.||eyes||Sánchez Alvarado and Newmark, 1999|
|porcupine-like||Protein involved in the pathway of lipid metabolism.||gut branches||Gurley et al., 2008|
|laminin-like||Fibrous protein present in the basement membrane of epithelia.||pharynx||Cebrià and Newmark, 2007|
|innexin||Transmembrane protein involved in the formation of channels permeable to ions and small molecules.||Protonephridia (kidney)||Oviedo and Levin, 2007|
|collagen||Elongated fibrils mostly found in fibrous tissues, such as muscle tissue.||muscle||Witchley et al., 2013|
|ifb||Intermediate filament protein B, a cytoplasmic molecule involved in mechanical strength and structure attachment in epidermal cells.||D/V edge||Molina et al., 2011|
|slit||Secreted midline protein with repulsive activity that prevents some cells to cross the body plan midline.||midline||Cebrià et al., 2007|
|sfrp-1||Secreted frizzled-related protein and modulator of wnt signaling.||anterior end||Gurley et al., 2008|
|frizzled-like||Wnt receptor involved in the maintenance of posterior tissues.||posterior end||Gurley et al., 2008|
Collins, J.J. 3rd, Hou, X., Romanova, E.V., Lambrus, B.G., Miller, C.M., Saberi, A., Sweedler, J.V. & Newmark, P.A. (2010). Genome-wide analyses reveal a role for peptide hormones in planarian germline development. PLOS Biology, 8, e1000509.
Reddien, P.W., Bermange, A.L., Murfitt, K.J., Jennings, J.R. & Sanchez Alvarado, A. (2005). Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria. Developmental Cell, 8, 635-649.